In vitro activity of tigecycline and other antibiotics against Burkholderia cepacia complex (Bcc) and other cystic fibrosis (CF)-associated Gram negative bacteria

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Burkholderia cepacia complex and cystic fibrosis

The bacteriae previously known as ‘Burkholderia cepacia’ have been reclassified as nine closely related species, sometimes referred to as ‘genomovars’ (Table 1), (Coenye et al, 2001; Mahenthiralingam et al, 2002). Collectively these are commonly referred to as ‘Burkholderia cepacia complex’ (Bcc). The various genomovars have different pathogenic potential (Keig et al, 1999; Bevivino et al, 2002...

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In vitro activity of LY146032 alone and in combination with other antibiotics against gram-positive bacteria.

The antibacterial activity of LY146032 alone and in combination with other drugs was assayed against gram-positive isolates. Synergism was found when LY146032 was combined with netilmicin, amikacin, imipenem, and fosfomycin by both checkerboard and time-kill tests. Indifference predominated when LY146032 was combined with teicoplanin, vancomycin, and rifampin. Under no circumstances and with no...

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In Vitro Antibacterial Activity of Several Plant Extracts and Oils against Some Gram-Negative Bacteria

Background: Medicinal plants are considered new resources for producing agents that could act as alternatives to antibiotics in the treatment of antibiotic-resistant bacteria. The aim of this study was to evaluate the antibacterial activity of 28 plant extracts and oils against four Gram-negative bacterial species.Methods: Experimental, in vitro, evaluation of the activities of 28 plant extract...

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Interactions of Burkholderia cenocepacia and other Burkholderia cepacia complex bacteria with epithelial and phagocytic cells.

Burkholderia cenocepacia is a member of the B. cepacia complex (Bcc), a group of opportunistic bacteria that infect the airways of patients with cystic fibrosis (CF) and are extraordinarily resistant to almost all clinically useful antibiotics. Infections in CF patients with Bcc bacteria generally lead to a more rapid decline in lung function, and in some cases to the 'cepacia syndrome', a virt...

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Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis

BACKGROUND Pseudomonas aeruginosa is the most common bacterial pathogen in patients with cystic fibrosis (CF). Current infection control guidelines aim to prevent transmission via contact and respiratory droplet routes and do not consider the possibility of airborne transmission. It was hypothesised that subjects with CF produce viable respirable bacterial aerosols with coughing. METHODS A cr...

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ژورنال

عنوان ژورنال: Journal of Cystic Fibrosis

سال: 2009

ISSN: 1569-1993

DOI: 10.1016/s1569-1993(09)60140-5